PDE10A, phosphodiesterase 10A, 10846

N. diseases: 97; N. variants: 26
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs147212971
rs147212971
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0428883
Disease:
Diastolic blood pressure 		T 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 28135244 2017
dbSNP: rs2934844
rs2934844
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005612
Disease:
Birth Weight 		T 0.700 GeneticVariation GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
dbSNP: rs875989839
rs875989839
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310792
Disease:
DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET 		G 0.800 CausalMutation CLINVAR
dbSNP: rs875989840
rs875989840
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310791
Disease:
STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2 		G 0.800 CausalMutation CLINVAR
dbSNP: rs875989841
rs875989841
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310791
Disease:
STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2 		G 0.800 CausalMutation CLINVAR
dbSNP: rs2983511
rs2983511
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		G 0.700 GeneticVariation GWASCAT Four loci previously associated with TSH in adults were confirmed in this study population (PDE10A (rs2983511: β = 0.112SD, p = 4.8 ∙ 10-16), FOXE1 (rs7847663: β = 0.223SD, p = 1.5 ∙ 10-20), NR3C2 (rs9968300: β = 0.194SD), p = 2.4 ∙ 10-11), VEGFA (rs2396083: β = 0.088SD, p = 2.2 ∙ 10-10)). 28333968 2017
dbSNP: rs753760
rs753760
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		C 0.800 GeneticVariation GWASDB A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs753760
rs753760
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		C 0.800 GeneticVariation GWASCAT A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs7762160
rs7762160
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0149654
Disease:
Conduct Disorder 		C 0.800 GeneticVariation GWASCAT Genome-wide association study of conduct disorder symptomatology. 20585324 2011
dbSNP: rs778899140
rs778899140
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310792
Disease:
DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET 		C 0.800 CausalMutation CLINVAR
dbSNP: rs1554258695
rs1554258695
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310791
Disease:
STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1554258695
rs1554258695
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310792
Disease:
DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET 		C 0.700 GeneticVariation CLINVAR
dbSNP: rs3008034
rs3008034
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		C 0.700 GeneticVariation GWASCAT Whole-genome sequence-based analysis of thyroid function. 25743335 2015
dbSNP: rs753760
rs753760
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0441683
Disease:
Hormone measurement 		C 0.700 GeneticVariation GWASCAT A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs778899140
rs778899140
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C1858120
Disease:
Generalized hypotonia 		C 0.700 GeneticVariation CLINVAR
dbSNP: rs778899140
rs778899140
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0557874
Disease:
Global developmental delay 		C 0.700 GeneticVariation CLINVAR
dbSNP: rs9457107
rs9457107
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005612
Disease:
Birth Weight 		C 0.700 GeneticVariation GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
dbSNP: rs2983514
rs2983514
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0020676
Disease:
Hypothyroidism 		A 0.700 GeneticVariation GWASCAT Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. 30367059 2018
dbSNP: rs2983514
rs2983514
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0020550
Disease:
Hyperthyroidism 		A 0.700 GeneticVariation GWASCAT Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. 30367059 2018
dbSNP: rs7744143
rs7744143
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0428883
Disease:
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs7744143
rs7744143
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs903432
rs903432
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0428883
Disease:
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs903432
rs903432
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005586
Disease:
Bipolar Disorder 		0.800 GeneticVariation GWASCAT Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005586
Disease:
Bipolar Disorder 		0.800 GeneticVariation GWASDB Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011